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KMID : 0352719960200020173
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Journal of Ginseng Research
1996 Volume.20 No. 2 p.173 ~ p.178
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Screening of Antioxidative Components from Red Ginseng Saponin
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Abstract
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erobic cells are normally protected from the damage of free radicals by antioxidative enzymes such as superoxide dismutase (SOD), catalase, glutathione (GSH) peroxidase, GSH S-transferase and GSH reductase which scavenge free radicals as well as nonenzymatic antioxidants such as ceruloplasmin, albumin and nonprotein-SH including GSH. The effects of each component (ginsenoside Rb₁, Rb₁, Rc, Rd, Re, Rg₁, Rf, Rh₁and Rh₂) of red ginseng on the antioxidative enzyme activities were investigated in the liver in order to screen antioxidative components of red ginseng. Ginsenoside Rb₂and Rc showed a tendency to increase GSH peroxidase activity, while ginsenoside Rc significantly decreased Cu,Zn-SOD activity. Especially, ginsenoside Rh: significantly increased catalase activity. These results suggest that ginsenoside Rh2 is an important active component among total saponins of red ginseng.
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KEYWORD
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free radicals, antioxidative effect, catalase, GSH peroxidase, Cu, Zn-SOD
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